Passive case detection of Human African Trypanosomiasis in Côte d’Ivoire

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Lejon, Veerle; Kaba, Dramane; Kabore, Jacques; Buscher, Philippe; Kone, Minayégninrin; Kouame, Cyrille Mambo; Compaore, Charlie Franck Alfred; Jamonneau, Vincent, 2021, "Passive case detection of Human African Trypanosomiasis in Côte d’Ivoire", https://doi.org/10.23708/FNZDMZ, DataSuds, V2, UNF:6:h9Cy8G5/SAO4IaPoWCW0zg== [fileUNF]

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Description	In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripheral health centres becomes crucial. However, HAT case detection by the peripheral health system with limited resources requires adapted diagnostic tests and test algorithms. The objective of the DiTECT-HAT-WP2 study was to determine the diagnostic performance and cost of rapid diagnostic tests (RDTs) performed on clinical suspects in peripheral health centres, whether or not followed by serological and/or molecular tests on filter paper done at regional reference centres. DiTECT-HAT has been registered in clinicaltrials.gov under ID NCT03356665, and is part of the DiTECT-HAT project, funded by EDCTP2-Horizon 2020- European Union. The DiTECT-HAT-WP2 study was conducted in centres for diagnosis and treatment and in sites for serological screening in Guinea, Côte d’Ivoire and DR Congo. In these centres and sites, clinical suspects were tested with several commercially available RDTs for HAT. Clinical suspects with at least 1 RDT positive result, 1° underwent parasitological examination and 2° blood collection on filter paper for reference analysis in trypanolysis, LAMP, ELISA and real-time PCR in the regional reference laboratory. If the reference laboratory tests and parasitological examinations were all negative, the suspect was considered free of HAT. If at least 1 reference test was positive, parasitological examinations were repeated at least twice at three months interval, unless trypanosomes were detected. The deposited file contains the DiTECT-HAT-WP2 study protocol in French and English, the informed consent form, and metadata of DiTECT-HAT-WP2 in Côte d'Ivoire. DiTECT-HAT-WP2 data will be made available to qualified researchers upon request after signing a confidentiality agreement. Data requests may be sent to the coordinating investigator (for coordinates see study protocol, Institut de Recherche pour le Développement). (2021-04-21)
Subject	Medicine, Health and Life Sciences
Keyword	neglected disease, Trypanosoma brucei gambiense, parasitology, Point-of-Care Testing, diagnosis, African trypanosomiasis, Serologic tests
Notes	Manuscript submitted for publication. Data type: Survey data
License/Data Use Agreement	Custom Dataset Terms

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	DiTECT-HAT-WP2-CI-deidentified-2021-05-04.tab DiTECT-HAT/Tabular Data - 529.4 KB Published Jul 20, 2021 4 Downloads 50 Variables, 3433 Observations UNF:6:h9Cy8G5/SAO4IaPoWCW0zg== DiTECT-HAT-WP2 de-identified data (data dictionary: refer to DiTECT-HAT-WP2-CI-deidentified-2021-05-04 Metadata.docx) DataSurvey	Access File File Access Restricted Users may not request access to files. Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-CI-deidentified-2021-05-04_Metadata.docx DiTECT-HAT/MS Word - 16.6 KB Published Jun 24, 2021 13 Downloads MD5: 87d5aea95e259fd0b98ef114ea9e7b00 DiTECT-HAT-WP2 Côte d'Ivoire metadata Documentation	Access File File Access Public Download Options MS Word Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-ICF_AF-V1_1F-17-01-09.pdf DiTECT-HAT/Adobe PDF - 622.3 KB Published Jun 24, 2021 17 Downloads MD5: e6859745e7c41a5ae93828d3588cdf59 DiTECT-HAT-WP2 Informed consent form and ascent form Documentation	Preview "DiTECT-HAT/DiTECT-HAT-WP2-ICF_AF-V1_1F-17-01-09.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-Protocol-V1_2E-17-01-09.pdf DiTECT-HAT/Adobe PDF - 1.9 MB Published Jun 24, 2021 17 Downloads MD5: ff5e9506b784d9bdb8b63ca3809d5238 DiTECT-HAT-WP2 study protocol, English Documentation	Preview "DiTECT-HAT/DiTECT-HAT-WP2-Protocol-V1_2E-17-01-09.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-Protocol-V1_2F-17-01-09.pdf DiTECT-HAT/Adobe PDF - 2.2 MB Published Jun 24, 2021 16 Downloads MD5: b26bfac54b600072c0a232905b78aaac DiTECT-HAT-WP2 study protocol, French Documentation	Preview "DiTECT-HAT/DiTECT-HAT-WP2-Protocol-V1_2F-17-01-09.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX

Citation Metadata

Persistent Identifier	doi:10.23708/FNZDMZ
Publication Date	2021-06-24
Title	Passive case detection of Human African Trypanosomiasis in Côte d’Ivoire
Subtitle	DiTECT-HAT-WP2-Côte d'Ivoire
Alternative URL	https://www.clinicaltrials.gov/ct2/show/NCT03356665?term=DiTECT-HAT&draw=2&rank=2
Author	Lejon, Veerle (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France) - ORCID: 0000-0002-6795-0962 Kaba, Dramane (Institut Pierre Richet - Côte d'Ivoire) - ORCID: 0000-0001-7103-0440 Kabore, Jacques (CIRDES - Burkina Faso) Buscher, Philippe (Institute of Tropical Medicine - Belgium) - ORCID: 0000-0002-1926-7472 Kone, Minayégninrin (Institut Pierre Richet - Côte d'Ivoire) Kouame, Cyrille Mambo (Institut Pierre Richet - Côte d'Ivoire) Compaore, Charlie Franck Alfred (CIRDES - Burkina Faso) Jamonneau, Vincent (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France) - ORCID: 0000-0001-8427-0769
Point of Contact	Use email button above to contact. Lejon, Veerle (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France)
Description	In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripheral health centres becomes crucial. However, HAT case detection by the peripheral health system with limited resources requires adapted diagnostic tests and test algorithms. The objective of the DiTECT-HAT-WP2 study was to determine the diagnostic performance and cost of rapid diagnostic tests (RDTs) performed on clinical suspects in peripheral health centres, whether or not followed by serological and/or molecular tests on filter paper done at regional reference centres. DiTECT-HAT has been registered in clinicaltrials.gov under ID NCT03356665, and is part of the DiTECT-HAT project, funded by EDCTP2-Horizon 2020- European Union. The DiTECT-HAT-WP2 study was conducted in centres for diagnosis and treatment and in sites for serological screening in Guinea, Côte d’Ivoire and DR Congo. In these centres and sites, clinical suspects were tested with several commercially available RDTs for HAT. Clinical suspects with at least 1 RDT positive result, 1° underwent parasitological examination and 2° blood collection on filter paper for reference analysis in trypanolysis, LAMP, ELISA and real-time PCR in the regional reference laboratory. If the reference laboratory tests and parasitological examinations were all negative, the suspect was considered free of HAT. If at least 1 reference test was positive, parasitological examinations were repeated at least twice at three months interval, unless trypanosomes were detected. The deposited file contains the DiTECT-HAT-WP2 study protocol in French and English, the informed consent form, and metadata of DiTECT-HAT-WP2 in Côte d'Ivoire. DiTECT-HAT-WP2 data will be made available to qualified researchers upon request after signing a confidentiality agreement. Data requests may be sent to the coordinating investigator (for coordinates see study protocol, Institut de Recherche pour le Développement). (2021-04-21)
Subject	Medicine, Health and Life Sciences
Keyword	neglected disease (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68058069 Trypanosoma brucei gambiense (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68014347 parasitology (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68010274 Point-of-Care Testing (Mesh) https://www.ncbi.nlm.nih.gov/mesh/2009759 diagnosis (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68003933 African trypanosomiasis (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68014353 Serologic tests (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68012698
Scientific Theme	Medical entomology, parasitology and virology (NumeriSud) https://uri.ird.fr/so/kos/tnu/052
Notes	Manuscript submitted for publication. Data type: Survey data
Language	English; French
Producer	Kaba, Dramane (Institut Pierre Richet) (IPR) https://iprci.org/ Lejon, Veerle (Institut de Recherche pour le Développement) (IRD) https://umr-intertryp.cirad.fr/
Production Date	2021-04-21
Production Location	Côte d'Ivoire
Contributor	Data Collector : Koné, Minayegninrin Data Manager : Büscher, Philippe Supervisor : Kaba, Dramane Work Package Leader : Kaboré, Jacques Data Collector : Kouamé, Cyrille Mambo Project Member : Compaoré, Charlie Franck Alfred Researcher : Jamonneau, Vincent Related Person : Koffi, Mathurin
Funding Information	EDCTP2: DRIA2014-306
Distributor	Lejon Veerle (IRD) (IRD) https://umr-intertryp.cirad.fr/
Depositor	Lejon, Veerle
Deposit Date	2021-04-21
Time Period	Start Date: 2017-08-01 ; End Date: 2020-12-31
Series	WP2, Côte d'Ivoire
Software	excel
Related Material	https://www.ditect-hat.eu/ https://publications.edctp.org/international-partnerships-against-infectious-diseases/ditec-hat https://www.clinicaltrials.gov/ct2/show/NCT03356665?term=DiTECT-HAT&draw=2&rank=2

Geospatial Metadata

Geographic Coverage	Côte d'Ivoire Bonon, Sinfra
Geographic Bounding Box	-6.241150139831007 -5.620422600768507 7.151766281372361 6.4945317524652

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