Passive case detection of Human African Trypanosomiasis in Guinea: symptoms and signs, rapid diagnostic test results and laboratory test results

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Lejon, Veerle; Camara, Oumou; Camara, Mamadou; Ilboudo, Hamidou; Kaboré, Jacques; Compaoré, Charlie Franck Alfred; Buscher, Philippe; Bucheton, Bruno, 2022, "Passive case detection of Human African Trypanosomiasis in Guinea: symptoms and signs, rapid diagnostic test results and laboratory test results", https://doi.org/10.23708/ZDD0OW, DataSuds, V1, UNF:6:5xfmuyoW9wsYi66d23V96w== [fileUNF]

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Description	In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripheral health centres becomes crucial. However, HAT case detection by the peripheral health system with limited resources requires adapted diagnostic tests and test algorithms. The objective of the DiTECT-HAT-WP2 study was to determine the diagnostic performance and cost of rapid diagnostic tests (RDTs) performed on clinical suspects in peripheral health centres, whether or not followed by serological and/or molecular tests on filter paper done at regional reference centres. DiTECT-HAT has been registered in clinicaltrials.gov under ID NCT03356665, and is part of the DiTECT-HAT project, funded by EDCTP2-Horizon 2020- European Union. The DiTECT-HAT-WP2 study was conducted in centres for diagnosis and treatment and in sites for serological screening in Guinea, Côte d’Ivoire and DR Congo. In these centres and sites, clinical suspects were tested with several commercially available RDTs for HAT. Clinical suspects with at least 1 RDT positive result, 1° underwent parasitological examination and 2° blood collection on filter paper for reference analysis in trypanolysis, LAMP, ELISA and real-time PCR in the regional reference laboratory. If the reference laboratory tests and parasitological examinations were all negative, the suspect was considered free of HAT. If at least 1 reference test was positive, parasitological examinations were repeated at least twice at three months interval, unless trypanosomes were detected. The deposited file contains the DiTECT-HAT-WP2 study protocol in French and English, the informed consent form, and metadata of DiTECT-HAT-WP2 in Guinea. DiTECT-HAT-WP2 data will be made available to qualified researchers upon request after signing a confidentiality agreement. Data requests may be sent to the coordinating investigator (for coordinates see study protocol, Institut de Recherche pour le Développement). (2022-10-12)
Subject	Medicine, Health and Life Sciences
Keyword	neglected disease, Trypanosoma brucei gambiense, parasitology, Point-of-Care Testing, diagnosis, African trypanosomiasis, Serologic tests
Notes	Data type: Survey data
License/Data Use Agreement	Custom Dataset Terms

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	1 to 5 of 5 Files	Original Format Archival Format (.tab) Request Access
	DiTECT-HAT-WP2-GN-deidentified-2022-10-12 Metadata.docx DiTECT-HAT/MS Word - 16.0 KB Published Oct 13, 2022 8 Downloads MD5: 9fa7421eb9c0fc53ff7ab8e054087e19 Metadata of data file DiTECT-HAT-WP2-GN-deidentified-2022-10-12 (data dictionary, in French and in English) Documentation	Access File File Access Public Download Options MS Word Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-GN-deidentified-2022-10-12.tab DiTECT-HAT/Tabular Data - 458.0 KB Published Oct 13, 2022 0 Downloads 62 Variables, 2402 Observations UNF:6:5xfmuyoW9wsYi66d23V96w== DiTECT-HAT-WP2 de-identified data (data dictionary: refer to DiTECT-HAT-WP2-GN-deidentified-2022-10-12 Metadata.docx) Data	Access File File Access Restricted Request Access Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-ICF_AF-V1_2 guineeF-17-03-23clean.pdf DiTECT-HAT/Adobe PDF - 617.4 KB Published Oct 13, 2022 7 Downloads MD5: e7aeb2275fff6c1e7f0db04403889be7 Informed consent form and assent form, in French Documentation	Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-Protocol-V1_2E-17-01-09.pdf DiTECT-HAT/Adobe PDF - 1.9 MB Published Oct 13, 2022 8 Downloads MD5: ff5e9506b784d9bdb8b63ca3809d5238 Study protocol in English Documentation	Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	DiTECT-HAT-WP2-Protocol-V1_2F-17-01-09.pdf DiTECT-HAT/Adobe PDF - 2.2 MB Published Oct 13, 2022 7 Downloads MD5: b26bfac54b600072c0a232905b78aaac Study protocol in French Documentation	Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX

Citation Metadata

Persistent Identifier	doi:10.23708/ZDD0OW
Publication Date	2022-10-13
Title	Passive case detection of Human African Trypanosomiasis in Guinea: symptoms and signs, rapid diagnostic test results and laboratory test results
Subtitle	DiTECT-HAT-WP2-Guinea
Alternative URL	https://www.clinicaltrials.gov/ct2/show/NCT03356665?term=DiTECT-HAT&draw=2&rank=2
Author	Lejon, Veerle (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France) - ORCID: 0000-0002-6795-0962 Camara, Oumou (PNLTHA - Guinée) Camara, Mamadou (PNLTHA - Guinée) Ilboudo, Hamidou (Institut de Recherche en Sciences de la Santé, Unité de Recherche Clinique de Nanoro - Burkina Faso) - ORCID: 0000-0003-3936-7718 Kaboré, Jacques (CIRDES - Burkina Faso) Compaoré, Charlie Franck Alfred (CIRDES - Burkina Faso) Buscher, Philippe (Institute of Tropical Medicine - Belgium) - ORCID: 0000-0002-1926-7472 Bucheton, Bruno (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France) - ORCID: 0000-0003-3804-5426
Point of Contact	Use email button above to contact. Lejon, Veerle (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France)
Description	In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripheral health centres becomes crucial. However, HAT case detection by the peripheral health system with limited resources requires adapted diagnostic tests and test algorithms. The objective of the DiTECT-HAT-WP2 study was to determine the diagnostic performance and cost of rapid diagnostic tests (RDTs) performed on clinical suspects in peripheral health centres, whether or not followed by serological and/or molecular tests on filter paper done at regional reference centres. DiTECT-HAT has been registered in clinicaltrials.gov under ID NCT03356665, and is part of the DiTECT-HAT project, funded by EDCTP2-Horizon 2020- European Union. The DiTECT-HAT-WP2 study was conducted in centres for diagnosis and treatment and in sites for serological screening in Guinea, Côte d’Ivoire and DR Congo. In these centres and sites, clinical suspects were tested with several commercially available RDTs for HAT. Clinical suspects with at least 1 RDT positive result, 1° underwent parasitological examination and 2° blood collection on filter paper for reference analysis in trypanolysis, LAMP, ELISA and real-time PCR in the regional reference laboratory. If the reference laboratory tests and parasitological examinations were all negative, the suspect was considered free of HAT. If at least 1 reference test was positive, parasitological examinations were repeated at least twice at three months interval, unless trypanosomes were detected. The deposited file contains the DiTECT-HAT-WP2 study protocol in French and English, the informed consent form, and metadata of DiTECT-HAT-WP2 in Guinea. DiTECT-HAT-WP2 data will be made available to qualified researchers upon request after signing a confidentiality agreement. Data requests may be sent to the coordinating investigator (for coordinates see study protocol, Institut de Recherche pour le Développement). (2022-10-12)
Subject	Medicine, Health and Life Sciences
Keyword	neglected disease (mesh) https://www.ncbi.nlm.nih.gov/mesh/68058069 Trypanosoma brucei gambiense (mesh) https://www.ncbi.nlm.nih.gov/mesh/68014347 parasitology (mesh) https://www.ncbi.nlm.nih.gov/mesh/68010274 Point-of-Care Testing (Mesh) https://www.ncbi.nlm.nih.gov/mesh/2009759 diagnosis (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68003933 African trypanosomiasis (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68014353 Serologic tests (Mesh) https://www.ncbi.nlm.nih.gov/mesh/68012698
Scientific Theme	Medical entomology, parasitology and virology (NumeriSud) https://uri.ird.fr/so/kos/tnu/052
Notes	Data type: Survey data
Language	English; French
Producer	Camara, Oumou (PNLTHA - Guinée) Camara, Mamadou (PNLTHA - Guinée) Lejon, Veerle (UMR INTERTRYP - IRD, CIRAD, Univ.Montpellier - France) https://umr-intertryp.cirad.fr/
Production Date	2021-02-01
Production Location	Guinea, Guinea
Contributor	Data Collector : Camara, Oumou Data Manager : Buscher, Philippe Supervisor : Camara, Mamadou Researcher : Ilboudou, Hamidou Work Package Leader : Kaboré, Jacques Project Member : Compaoré, Charlie Franck Alfred
Funding Information	EDCTP2 Horizon 2020 European Union: DRIA-2014-306-DiTECT-HAT
Distributor	Lejon, Veerle (Institut de recherche pour le développement) https://umr-intertryp.cirad.fr/
Depositor	Lejon, Veerle
Deposit Date	2022-10-12
Time Period	Start Date: 2017-01-15 ; End Date: 2021-03-31
Series	WP2, Guinée
Software	Excel
Related Material	https://www.clinicaltrials.gov/ct2/show/NCT03356665?term=DiTECT-HAT&draw=2&rank=2

Geospatial Metadata

Geographic Coverage	Guinea
Geographic Bounding Box	-14.458008147776129 -13.11767611652613 10.174374687521418 9.069551956402043

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