Insecticide resistance management in Burkina Faso and Côte d'Ivoire: research on vector control strategies

The fight against malaria faces now the challenge of the emergence and expansion of the resistance to both curative (drugs) and preventive (vector control) tools. Vector control which relies primarily on mass distribution of long lasting pyrethroid-treated nets contributes to the reduction of malaria transmission. The resistance of Anopheles vectors to pyrethroids, the only insecticide class recommended to treat bed nets, is threatening the considerable progresses made over the last decade. The REACT project aims to assess whether addition of complementary vector control strategies to long- lasting insecticidal mosquito nets provides additional protection against clinical malaria in areas with pyrethroid-resistant vectors in rural Burkina Faso and Ivory Coast. The tested strategies are 1) Indoor residual sprayings of insecticide; 2) intensive communication for human behavioural changes; 3) larviciding with natural toxins of Bacillus thurengiensis israelensis; 4) Use of Ivermectin both in human and cattle.
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Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
Jul 6, 2026
Moiroux, Nicolas; Taconet, Paul; Zogo, Barnabas; Tchiekoi, Bertin N'cho; Pennetier, Cedric, 2026, "Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.", https://doi.org/10.23708/PKVLDK, DataSuds, V1
This repository contains the protocol, the data and analyses scripts for a Randomized Controlled Trial evaluating Bti-based larviciding in combination to Long-Lasting Insecticidal Nets (LLIN) in Côte d'Ivoire (CI). A detailed description of the dataset organization and content is...
data2.RData
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
Gzip Archive - 59.2 KB - MD5: ad7aec573835191feff4473f4e04bcd7
Data
Data for bednet use analysis
data_meta_BTI.RData
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
R Data - 377 B - MD5: b8f192e0e1cc9c189a9b228481239a95
Data
Data for BTI-based larvicide meta-analysis
data.RData
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
Gzip Archive - 181.1 KB - MD5: 0f003051fb39a1e98187f2a4019d04bc
Data
Data for epidemiological outcomes analysis
DataUseAgreement_doi_10_23708_PKVLDK.docx
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
MS Word - 30.7 KB - MD5: 4e5aad39bb47f6be73212e6a8b723d85
Documentation
Data use agreement form. The form must be downloaded, completed and returned to the authors of the dataset and data@ird.fr before access to the data files is granted.
entomo.RData
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
Gzip Archive - 886.2 KB - MD5: ca522bab56f1780475ab392935fdbfd7
Data
Data for entomological outcomes analysis
Meta_analysis_LARV_update.R
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
R Syntax - 1.4 KB - MD5: 55410d99c940d781ed40b8f8215f31b0
Code
Data for Larvicide meta-analysis
metadata.Rmd
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
R Notebook - 27.2 KB - MD5: d5a33c7ba004079fb72f29891fc6663b
Documentation
R Markdown file of metadata and dataset descriptions (data dictionnary)
Primary outcome_Incidence rate_Analysis.R
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
R Syntax - 8.1 KB - MD5: 4b31cfad371ce87b7265149fdbfb0e79
Code
REACT_protocol.docx
Jul 6, 2026 - Protocol, Replication Data and Codes for: Effectiveness of a dry season larviciding strategy to complement universal coverage with long-lasting insecticidal nets against malaria.
MS Word - 74.2 KB - MD5: 4fff7b67ed1f92e4fffd50feb686d219
Documentation
This is the protocol of the REACT trial.
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