Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: a population-based cross-sectional study (the MorLo project)

Version 1.0

Chesnais, Cedric; Campillo, Jérémy; Dupasquier, Valentin; Lebredonchel, Elodie; Beneteau, Samuel; Rancé, Ludovic; Madoulou, Glorifié; Niama, Ange; Bileckot, Richard; Pion, Sébastien; Boussinesq, Michel; Missamou, François, 2025, "Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: a population-based cross-sectional study (the MorLo project)", https://doi.org/10.23708/KCEDO2, DataSuds, V1, UNF:6:fayZ8BhGmddSHb8r11mvcg== [fileUNF]

Learn about Data Citation Standards.

Contact Owner

Dataset Metrics

6 Downloads

Description	Background: Loa loa filariasis, a parasitic infection endemic to Central Africa, is a common cause of medical consultation in this region. Methods: To evaluate the quality of life (QoL) of individuals living in loiasis-endemic areas, we enrolled 991 subjects (one-third being microfilaremic) from the general population of a rural area in the Republic of Congo. QoL and disability were assessed using WHODAS 2.0 12-items and EQ-5D-5L questionnaires. We collected data on the number of eye worm (Ew) and Calabar swellings episodes experienced throughout their lives, as well as individual L. loa microfilarial densities and information on infections with soil-transmitted helminthiasis. Principal findings: Individuals with a history of Ew had a nearly doubled risk of experiencing moderate disability (score >25/100) (adjusted Odds-Ratio=1.77 (95%CI [1.05-2.99], p=0.033), compared to those without such a history. Those with more than 10 episodes of Ew during their lifetime had a 28% increase in overall disability as measured by WHODAS. No other variable related to loiasis (Calabar swelling frequency, L. loa microfilarial density and positivity to L. loa antibody rapid test) was associated with the various scores. Additionally, infection with Trichuris trichiura was associated to worse anxiety score (adjusted incidence risk ratio=1.22 (95% CI [1.06-1.39], p=0.004)). . Conclusions: The impact of loiasis on daily QoL appears to be primarily due to adult worms rather than microfilarial density. Adult worms would mainly affect daily activities through peripheral symptoms, such as joint-related discomfort (with notable mobility impairment), while microfilariae would primarily induce organ dysfunction. Further studies are needed to better understand the respective clinical impacts of adult worms and L. loa microfilariae. Team projects: https://www.ntd-researchgroup.com/morlo Fundings: This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 949221)
Subject	Medicine, Health and Life Sciences
Keyword	Filariasis, Loiasis, Africa, Quality of life, WHODAS, EQ-5D-5L
Related Publication	Marlhand C. Hemilembolo, Jérémy T. Campillo, Valentin Dupasquier, Elodie Lebredonchel, Samuel Beneteau, Ludovic G. Rancé, Glorifié Madoulou Moulabou, Ange Clauvel Niama, Richard R. Bileckot, Sébastien D. S. Pion, Michel Boussinesq, François Missamou, Cédric B. Chesnais 2025, " Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: a population-based cross-sectional study (the MorLo project)
License/Data Use Agreement	Custom Dataset Terms

Change View

Table

Tree

Filter by

	1 to 4 of 4 Files	Original Format Archival Format (.tab) Request Access
	Data_Use_Agreement_Template.pdf WHODAS_Loa_Congo_PlosNTD/Adobe PDF - 60.2 KB Published May 23, 2025 2 Downloads MD5: c315b2d8e14230adeed9a06ada7b154c Data use agreement template. The form must be downloaded, completed and returned to the authors of the dataset and data@ird.fr before access to the data files is granted. Documentation	Preview "WHODAS_Loa_Congo_PlosNTD/Data_Use_Agreement_Template.pdf" Access File File Access Public Download Options Adobe PDF Download Metadata Data File Citation EndNote XML RIS BibTeX
	ReadMe_KCEDO2.txt WHODAS_Loa_Congo_PlosNTD/Plain Text - 3.2 KB Published May 23, 2025 3 Downloads MD5: 50d40660aca5bc2534f84297b28beb6c Contains citation, description and conditions of use of dataset data Documentation	Preview "WHODAS_Loa_Congo_PlosNTD/ReadMe_KCEDO2.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation EndNote XML RIS BibTeX
	WHODAS_Loa_Congo_PlosNTD_Data.tab WHODAS_Loa_Congo_PlosNTD/Tabular Data - 279.1 KB Published May 23, 2025 0 Downloads 41 Variables, 991 Observations UNF:6:PqyFALRq3bZu/zOietLriw== Data from WHODAS 2.0 12-item and EQ-5D-5L questionnaires Données	Access File File Access Restricted Request Access Download Metadata Data File Citation EndNote XML RIS BibTeX
	WHODAS_Loa_Congo_PlosNTD_Dictionnary_Data.tab WHODAS_Loa_Congo_PlosNTD/Tabular Data - 2.5 KB Published May 23, 2025 1 Download 12 Variables, 36 Observations UNF:6:ui7L6W5QiM700BJWaUsesg== Data dictionnary Documentation	Preview "WHODAS_Loa_Congo_PlosNTD/WHODAS_Loa_Congo_PlosNTD_Dictionnary_Data.tab" Access File File Access Public Download Options Tab-Separated Values (Original File Format) Tab-Delimited RData Download Metadata Variable Metadata Data File Citation EndNote XML RIS BibTeX

Citation Metadata

Persistent Identifier	doi:10.23708/KCEDO2
Publication Date	2025-05-23
Title	Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: a population-based cross-sectional study (the MorLo project)
Author	Chesnais, Cedric (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France) - ORCID: 0000-0002-8779-977X Campillo, Jérémy (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France) - ORCID: 0000-0002-4400-5204 Dupasquier, Valentin (Department of Cardiology, Montpellier University Hospital, Montpellier, France) Lebredonchel, Elodie (Department of Biochemistry, Hôpitaux Universitaires Paris Nord Val de Seine – site Bichat, Assistance Publique des Hôpitaux de Paris, Paris, France) - ORCID: 0000-0001-5119-6005 Beneteau, Samuel (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France) - ORCID: 0000-0002-5922-3503 Rancé, Ludovic (Department of Anesthesiology and Critical Care Medicine, Montpellier University Hospital, Montpellier, France.) Madoulou, Glorifié (Programme National de Lutte contre l'Onchocercose, Direction de l'Épidémiologie et de la Lutte contre la Maladie, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo.) Niama, Ange (Faculté des Sciences de la santé, Université Marien Ngouabi, Brazzaville, Republic of Congo) - ORCID: 0000-0002-3103-2764 Bileckot, Richard (Faculté des Sciences de la santé, Université Marien Ngouabi, Brazzaville, Republic of Congo) Pion, Sébastien (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France) - ORCID: 0000-0002-9468-7020 Boussinesq, Michel (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France) - ORCID: 0000-0002-4400-5204 Missamou, François (Programme National de Lutte contre l'Onchocercose, Direction de l'Épidémiologie et de la Lutte contre la Maladie, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo.)
Point of Contact	Use email button above to contact. Chesnais, Cedric (UMI TransVIHMI - IRD, INSERM, Univ. Montpellier - France)
Description	Background: Loa loa filariasis, a parasitic infection endemic to Central Africa, is a common cause of medical consultation in this region. Methods: To evaluate the quality of life (QoL) of individuals living in loiasis-endemic areas, we enrolled 991 subjects (one-third being microfilaremic) from the general population of a rural area in the Republic of Congo. QoL and disability were assessed using WHODAS 2.0 12-items and EQ-5D-5L questionnaires. We collected data on the number of eye worm (Ew) and Calabar swellings episodes experienced throughout their lives, as well as individual L. loa microfilarial densities and information on infections with soil-transmitted helminthiasis. Principal findings: Individuals with a history of Ew had a nearly doubled risk of experiencing moderate disability (score >25/100) (adjusted Odds-Ratio=1.77 (95%CI [1.05-2.99], p=0.033), compared to those without such a history. Those with more than 10 episodes of Ew during their lifetime had a 28% increase in overall disability as measured by WHODAS. No other variable related to loiasis (Calabar swelling frequency, L. loa microfilarial density and positivity to L. loa antibody rapid test) was associated with the various scores. Additionally, infection with Trichuris trichiura was associated to worse anxiety score (adjusted incidence risk ratio=1.22 (95% CI [1.06-1.39], p=0.004)). . Conclusions: The impact of loiasis on daily QoL appears to be primarily due to adult worms rather than microfilarial density. Adult worms would mainly affect daily activities through peripheral symptoms, such as joint-related discomfort (with notable mobility impairment), while microfilariae would primarily induce organ dysfunction. Further studies are needed to better understand the respective clinical impacts of adult worms and L. loa microfilariae. Team projects: https://www.ntd-researchgroup.com/morlo Fundings: This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 949221)
Subject	Medicine, Health and Life Sciences
Keyword	Filariasis Loiasis Africa Quality of life WHODAS EQ-5D-5L
Scientific Theme	Health: generalities (NumeriSud) https://uri.ird.fr/so/kos/tnu/050
Related Publication	Marlhand C. Hemilembolo, Jérémy T. Campillo, Valentin Dupasquier, Elodie Lebredonchel, Samuel Beneteau, Ludovic G. Rancé, Glorifié Madoulou Moulabou, Ange Clauvel Niama, Richard R. Bileckot, Sébastien D. S. Pion, Michel Boussinesq, François Missamou, Cédric B. Chesnais 2025, " Disability and quality of life assessment using WHODAS-12 items 2.0 and EQ-5D-5L in a rural area endemic for loiasis in the Republic of Congo: a population-based cross-sectional study (the MorLo project)
Funding Information	ERC Starting Grant: 949963
Depositor	CHESNAIS, Cedric
Deposit Date	2025-03-04
Time Period	Start Date: 2022-04-15 ; End Date: 2028-07-31
Date of Collection	Start Date: 2022-06-01 ; End Date: 2022-07-10
Data Type	Analysis data

Geospatial Metadata

Geographic Coverage	Congo

Dataset Terms

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Custom Dataset Terms — the following Custom Dataset Terms have been defined for this dataset.

Documentation files

This work is licensed under a Creative Commons Attribution 4.0 International License.

Fichiers de documentation

Ce(tte) œuvre est mise à disposition selon les termes de la Licence Creative Commons Attribution 4.0 International.

Data files
Restricted access.

Fichiers de données
Accès restreint.

Restricted Files + Terms of Access

Restricted Files

There is 1 restricted file in this dataset.

Terms of Access for Restricted Files

This data set is sensitive because it contains pseudonymized personal health data. Any attempt to re-identify participants is strictly forbidden. Data are available on request from the authors by filling in and sending the “Data_use_agreement” form along with the dataset files, with a copy to DataSuds (data@ird.fr). Access to the data is subject to approval and a data-sharing agreement. This dataset may only be used for scientific research purposes, directly related to the project cited in the request for use.

Cet ensemble de données est sensible car il contient des données de santé personnelles pseudonymisées. Toute tentative de ré-identification des participants est strictement interdite. Les données sont disponibles sur demande auprès des auteurs en remplissant et en envoyant le formulaire « Data_use_agreement » avec les fichiers de l'ensemble de données, avec une copie à DataSuds (data@ird.fr). L'accès aux données est soumis à une approbation et à un accord de partage des données. Cet ensemble de données ne peut être utilisé qu'à des fins de recherche scientifique, directement liées au projet cité dans la demande d'utilisation.

Request Access

Users may request access to files.

Dataset Version	Summary	Edited by	Published on
No records found.

Edit File

This file has already been deleted (or replaced) in the current version. It may not be edited.

Restrict Access

Restricting limits access to published files. People who want to use the restricted files can request access by default. If you disable request access, you must add information about access to the Terms of Access field.

Learn about restricting files and dataset access in the User Guide.

Request Access

Enable access request

You must enable request access or add terms of access to restrict file access.

Terms of Access for Restricted Files

Save Changes

Edit Embargo

The selected file or files have already been published. Contact an administrator to change the embargo date or reason of the file or files.

Delete Files

The file will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Select File(s)

Please select one or more files.

Share Dataset

Share this dataset on your favorite social media networks.

Continue

Dataset Citations

Citations for this dataset are retrieved from Crossref via DataCite using Make Data Count standards. For more information about dataset metrics, please refer to the User Guide.

Sorry, no citations were found.

Restricted Files Selected

The selected file(s) may not be downloaded because you have not been granted access.

You may request access to the restricted file(s) by clicking the Request Access button.

Download Options

The files selected are too large to download as a ZIP.

You can select individual files that are below the 300.0 MB download limit from the files table, or use the Data Access API for programmatic access to the files.

Select File(s)

Please select a file or files to be downloaded.

Restricted Files Selected

The restricted file(s) selected may not be downloaded because you have not been granted access.

Click Continue to download the files you have access to download.

Ineligible Files Selected

Some file(s) cannot be transferred. (They are restricted, embargoed, or not Globus accessible.)

Click Continue to transfer the elligible files.

Delete Dataset

Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.

Delete Draft Version

Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.

Unpublished Dataset Private URL

Private URL can only be used with unpublished versions of datasets.

Unpublished Dataset Private URL

Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your unpublished dataset.

Delete Files

The file(s) will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Compute

This dataset contains restricted files you may not compute on because you have not been granted access.

Deaccession Dataset

Are you sure you want to deaccession? This is permanent and the selected version(s) will no longer be viewable by the public.

Deaccession Dataset

Are you sure you want to deaccession this dataset? This is permanent an it will no longer be viewable by the public.

Version Differences Details

Please select two versions to view the differences.

Version Differences Details

Version:
Last Updated:

Select File(s)

Please select a file or files for access request.

Select File(s)

Embargoed files cannot be accessed. Please select an unembargoed file or files for your access request.

Edit Tags

Select existing file tags or create new tags to describe your files. Each file can have more than one tag.

Request Access

You need to Log In to request access.

Dataset Terms

Please confirm and/or complete the information needed below in order to request access to files in this dataset.

This dataset is made available under the following terms. Please confirm and/or complete the information needed below in order to continue.

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Custom terms specific to this dataset Custom Dataset Terms — the following Custom Dataset Terms have been defined for this dataset.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Fichiers de documentation

Ce(tte) œuvre est mise à disposition selon les termes de la Licence Creative Commons Attribution 4.0 International.

Data files
Restricted access.

Fichiers de données
Accès restreint.

Name

Institution

Position

Preview Guestbook

Upon downloading files the guestbook asks for the following information.

Guestbook Name

Collected Data

Account Information

Package File Download

Use the Download URL in a Wget command or a download manager to download this package file. Download via web browser is not recommended. User Guide - Downloading a Dataverse Package via URL

Download URL

https://dataverse.ird.fr/api/access/datafile/

Compute Batch

Clear Batch

Dataset	Persistent Identifier	Change Compute Batch

Compute Batch

Submit for Review

You will not be able to make changes to this dataset while it is in review.

Publish Dataset

Are you sure you want to republish this dataset?

Select if this is a minor or major version update.

Minor Release (1.1)

Major Release (2.0)

Publish Dataset

This dataset cannot be published until UMI TransVIHMI is published by its administrator.

Publish Dataset

This dataset cannot be published until UMI TransVIHMI and DataSuds are published.

Return to Author

Return this dataset to contributor for modification. The reason for return entered below will be sent by email to the author.