Association between arterial stiffness and Loa loa microfilaremia in a rural area of the Republic of Congo: a population-based cross-sectional study (MorLo project): data and documentation

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Association between arterial stiffness and Loa loa microfilaremia in a rural area of the Republic of Congo: a population-based cross-sectional study (MorLo project): data and documentation
Campillo, Jeremy T.; Dupasquier, Valentin; Lebredonchel, Elodie; Rancé, Ludovic G.; Hemilembolo, Marlhand C.; Pion, Sébastien D. S.; Missamou, François; Perez Martin, Antonia; Chesnais, Cédric B., 2023, "Association between arterial stiffness and Loa loa microfilaremia in a rural area of the Republic of Congo: a population-based cross-sectional study (MorLo project): data and documentation", https://doi.org/10.23708/TEM4LQ, DataSuds, V1, UNF:6:L3HKqQiclp9jpWDWVRCCuw== [fileUNF]
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Description

Recent epidemiologic data suggested an increased mortality and morbidity in individuals harboring high densities of Loa loa microfilariae in the blood, underscoring the importance of studies on the possible reasons for this excess mortality.

As part of the MorLo project, this cross-sectional study assessed arterial stiffness and cardiovascular health markers using a point-of-care device (pOpmètre) among 991 sex-, age- and residency-matched individuals living in rural forested areas of Congo. These data were collected between May 2022 and June 2023.

Analyses included known cardiovascular risk factors (body mass index, smoking, blood pressure, creatininemia) and parasitological covariates (onchocerciasis, asymptomatic malaria, soil-transmitted helminths and Loa loa microfilaremia). People with microfilaremia were more likely to have levels of cardiovascular markers indicating arterial stiffness and deteriorated cardiovascular health, compared with those without microfilaremia.

(2023-12-05)
Subject Medicine, Health and Life Sciences
Keyword Loiasis, microfilaremia, arterial stiffness, cardiovascular health, filariasis, Republic of Congo
Related Publication Campillo, J.T., Dupasquier, V., Lebredonchel, E., Rancé, L.G., Hemilembolo, M.C., Pion, S.D.S., Boussinesq, M., Missamou, F., Perez Martin, A., Chesnais, C.B. (2024) Association between arterial stiffness and Loa loa microfilaremia in a rural area of the Republic of Congo: A population-based cross-sectional study (the MorLo project). PLoS Neglected Tropical Diseases 18(1). doi: 10.1371/journal.pntd.0011915
Notes This study received approval from the Ethics Committee of the Congolese Foundation for Medical Research (N° 036/CIE/FCRM/2022) and the Congolese Ministry of Health and Population (N° 376/MSP/CAB/UCPP-21). All participants received clear and appropriate information and signed an informed consent form for this specific study.
The provided data was anonymized by suppression of variables and generalization (value categorization, e.g. ages and weights). Anonymization was verified through ARX software.
Data type: Analysis data
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Arterial_Stiffness-Loa-Data.tab
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29 Variables, 991 Observations UNF:6:FlUjFgnbXJSW82L0Bfethw==
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8 Variables, 28 Observations UNF:6:IeaEnHVriUYNtKJNauUH3g==
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CRF_MorLo-CONGO_suivi_cohorte-1000.pdf
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