The MiPPAD randomized trial was set up in 2009 to compare the effectiveness of two intermittent preventive treatments of malaria in pregnancy (IPTp), sulfadoxine-pyrimethamine and mefloquine. This trial took place in several sub-Saharan African countries: Benin, Mozambique, Gabon, and Tanzania.
Since then, offspring born within this trial have been monitored in Benin to better understand the risk factors for children’s neurodevelopment and health. The MiPPAD trial enrolled 1,183 HIV-negative pregnant women in Benin. The MiPPAD cohort of Benin assessed 767, 590, and 471 children at 1, 6, 9, and 14 years, respectively.
The cohort takes place in a semi rural area in the district of Allada, including Allada, Sekou and Attogon, in Benin, sub-Saharan Africa.
Information was collected on infectious diseases (malaria, helminths), nutritional (iron deficiency, anemia), psychosocial and environmental (metals, pesticides) factors throughout pregnancy, childhood, and adolescence. Outcomes assessed included child’s neurodevelopment, mental health, growth, asthma, allergies, cardiometabolic health and puberty. In Mozambique, offspring born within the MiPPAD trial were also assessed in the same way at the age of 14.
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The MiPPAD birth cohort of Benin - Follow-up at six years
The MiPPAD birth cohort of Benin - Follow-up at six years
Mar 6, 2026
Bodeau-Livinec, Florence; Zoumenou, Roméo Eseyelogni; Fermanian, Christophe; Massougbodji, Achille, 2026, "The MiPPAD birth cohort of Benin - Follow-up at six years", https://doi.org/10.23708/WZ9A8P, DataSuds, V1
The MiPPAD birth cohort of Benin has for overall objective to study the early determinants of children's health and development. The cohort followed offspring born to pregnant women included in the MiPPAD trial. This six year follow-up included data collection on offspring neurod...
The MiPPAD birth cohort of Benin - Follow-up at fourteen years
The MiPPAD birth cohort of Benin - Follow-up at fourteen years
Mar 6, 2026
Bodeau-Livinec, Florence; Zoumenou, Roméo Eseyelogni; Fermanian, Christophe; Massougbodji, Achille, 2026, "The MiPPAD birth cohort of Benin - Follow-up at fourteen years", https://doi.org/10.23708/LZCJLC, DataSuds, V1
The MiPPAD birth cohort of Benin has for overall objective to study the early determinants of children's health and development. The 14-year follow-up included offspring born to pregnant women included in the MiPPAD trial. This follow-up included data collection on offspring neur...
The MiPPAD birth cohort of Benin - Follow-up at one year
The MiPPAD birth cohort of Benin - Follow-up at one year
Jan 20, 2026
Bodeau-Livinec, Florence; Zoumenou, Roméo Eseyelogni; Fermanian, Christophe; Massougbodji, Achille, 2026, "The MiPPAD birth cohort of Benin - Follow-up at one year", https://doi.org/10.23708/ZCIPAX, DataSuds, V1
The MiPPAD birth cohort of Benin has for overall objective to study the early determinants of children's health and development. The TOVI project followed offspring born to pregnant women included in the MiPPAD trial. This one year follow-up included data collection on offspring...
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